Optimal heart health depends on many factors, including proper endothelial function.1 Even with cholesterol/glucose levels in the healthy range, aging individuals need to maintain youthful integrity of their endothelium—the thin layer of cells lining the interior of the entire circulatory system.
Based on published studies showing improvements in endothelial function, health-conscious people have been drinking pomegranate juice or taking a standardized pomegranate supplement.
Going Beyond Pomegranate
The addition of CORDIART™ (extract from sweet orange peels) to pomegranate provides another vascular benefit by activating endothelial production of nitric oxide, which signals the smooth muscles to relax, inducing vasodilation to support healthy circulation.
In clinical research, 500 mg of CORDIART™ alone produced an 18% improvement in flow mediated dilation, a direct marker of endothelial function. CORDIART™ also inhibited the pro-inflammatory factors C-reactive protein and serum amyloid A that interrupt healthy nitric oxide production.2
For those seeking the convenience of three nutrients clinically shown to help with blood flow and age-related changes in endothelial function,2-6 the newly formulated Endothelial Defense™ provides GliSODin®, Full-Spectrum Pomegranate™, and CORDIART™.
The orally active form of superoxide dismutase (SOD)—called GliSODin®—has been clinically demonstrated to support healthy arterial function and structure, while boosting levels of the body’s protective enzymes—SOD and catalase.4-6 The new Endothelial Defense contains a potent dose of GliSODin® along with 500 mg of CORDIART™.
The new Endothelial Defense™ also provides standardized pomegranate juice extract and a proprietary pomegranate flower and seed oil blend. These extracts from different parts of the pomegranate plant provide potent polyphenols clinically shown to support healthy blood flow, youthful lipid and glucose metabolism, and healthy inflammatory factors.2,3,7-9
Endothelial Defense™ with Full-Spectrum Pomegranate™ and CORDIART™ addresses many factors that promote youthful endothelial function in a dose of two softgel capsules daily.
1. Annu Rev Physiol. 2006;68:51-66.
2. Bioactor B.V.;2013.
3. Altern Med Rev. 2008 Jun;13(2):128.
4. Eur Ann Allergy Clin Immunol. 2007 Feb;39(2):45-50.
5. Phytother Res. 2004 Dec;18(12):957-62.
6. Free Radic Res. 2004 Sep;38(9):927-32.
7. Adv Biomed Res. 2014; 3:100.
8. J Nutr Sci. 2012; 1:e9.
9. Biofactors. 2015 Jan-Feb;41(1):44-51.
(Reprinted from Life Extension – Endothelial Defense™ with Full-Spectrum Pomegranate™ and CORDIART™)